Don't pop a pill after you work out. Researchers at the University of Arkansas for Medical Sciences found that ibuprofen (Advil, Motrin) and acetaminophen (Tylenol) were no more effective than a placebo in relieving post exercise muscle soreness.
More important, they say the drugs may actually suppress muscle growth when taken after a workout.
Instead of reaching for a pill, try taking a walk or doing some light stretching to ease those muscles. If you have access to a gym, you can sit in a sauna for a few minutes to loosen your muscles. Afterwards, stretch the muscles that are bothering you to help relieve the soreness. Be sure to warm up your muscles before stretching!
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